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KMID : 0857020060210010275
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Kosin Medical Journal
2006 Volume.21 No. 1 p.275 ~ p.283
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Association Between Polymorphism Exon 1 Variant (G→A) at the Locus of the Scavenger Receptor Class B Type-Ⅰ Gene and Metabolic Syndrome
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Park Chun-Ho
Lee Yong-Hwan
Yu Byeng-Chul
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Abstract
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Background and Objectives: Several lifestyle habits may predispose to the metabolic syndrome. Among them there is evidence that quality and quantity of fatty acids could play a key role in the development of metabolic syndrome. There is also evidence for the involvement of genetic factors in the etiology of this condition. The association between polymorphism in the scavenger receptor class B type Ⅰ(SR-BI) gene and variations in basal plasma concentrations of cholesterol in humans recently has been described. The objective of this study was to determine whether the exon 1 variant (G→A) at the locus of SR-BI gene is associated with metabolic syndrome.
Methods: A total of 364 health screen examinees were enrolled in this study who were examined in Kosin University Gospel Hospital from December 2004 to July 2005. The height, weight, waist circumference, and systolic and diastolic blood pressure of the subjects were examined and fasting blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride were measured by sampling in venous blood. The metabolic syndrome was defined as the presence of three or more of the following: waist circumference in men ≥90 cm, in women ≥80 cm, blood pressure ≥130/85 mmHg, fasting glucose ≥110 mg/dL, HDL cholesterol in men <40 mg/dL, in women <50 mg/dL, and triglyceride ≥150 mg/dL. The blood pressure, fasting glucose, HDL cholesterol, triglyceride were evaluated by using the criteria of NECP ATP Ⅲ and waist circumference was assessed by using the criteria of WHO Asia-Western Pacific. Allelic discrimination of the SR-BI exon 1 was performed by PCR-RFLP method.
Results: The frequences of AG of the SR-BI exon 1 polymorphism were 29.0% for the metabolic syndrome, 16.7% for the control, and 25% in total subjects. There were no significant differences in the comparisons of components of metabolic syndrome according to polymorphism at the SR-BI exon 1 locus.
Conclusion: It is necessary to study about the relationship between polymorphism exon 1 variant at the locus of SR-BI gene and metabolic syndrome.
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KEYWORD
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Metabolic syndrome, SR-B, I Genetic polymorphism
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